FMS-related tyrosine kinase 3 internal tandem duplication (FLT3-ITD): a villain among others
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منابع مشابه
FMS-related tyrosine kinase 3 internal tandem duplication (FLT3-ITD): a villain among others
cute myeloid leukemia (AML) is the most frequent acute eukemia of adult patients with an estimated 10,070 new cases n Brazil in 2016. Most of the cases are de novo, without a efined etiology, and around two thirds of the patients will die f the disease, according to the Instituto Nacional de Câncer INCA).1 Genetic aberrations may help to differentiate patients ho have a good from those with a d...
متن کاملActivating internal tandem duplication mutations of the fms-like tyrosine kinase-3 (FLT3-ITD) at complete response and relapse in patients with acute myeloid leukemia.
FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutations are among the most frequent molecular aberrations in patients with acute myeloid leukemia. We retrospectively analyzed 324 patients with acute myeloid leukemia treated with front-line induction chemotherapy between October 2004 and March 2010. Fifty-six patients had FLT3-ITD mutation at diagnosis. Fifty-one (91%) patien...
متن کاملFLT3 (FMS-like tyrosine kinase 3)
Size: 993 amino acids; 112804 Da; FLT3 is a class III receptor tyrosine kinase (RTK) structurally related to the receptors for platelet derived growth factor (PDGF), colony stimulating factor 1 (CSF1), and KIT ligand (KL).; these RTK contain five immunoglobulin-like domains in the extracellular region and an intracelular tyrosine kinase domain splitted in two by a specific hydrophilic insertion...
متن کاملFLT3 (FMS-like tyrosine kinase 3)
993 amino acids; FLT3 is a class III receptor tyrosine kinase (RTK) structurally related to the receptors for platelet derived growth factor (PDGF), colony stimulating factor 1 (CSF1), and KIT ligand (KL); these RTK contain five immunoglobulin-like domains in the extracellular region and an intracelular tyrosine kinase domain split in two by a specific hydrophilic insertion (kinase insert); imm...
متن کاملSorafenib-induced Thyroiditis in FMS-like Tyrosine Kinase 3-internal Tandem Duplication-mutated Acute Myeloid Leukemia
Correspondence To the Editor: Sorafenib is a novel, orally available inhibitor of multiple kinases. It has been used in relapsed and refractory FMS‑like tyrosine kinase (FLT)‑3‑positive acute myeloid leukemia (AML) in recent years with favorable outcomes. Thyroiditis and hypothyroidism as side effects have been reported in treatment on renal cell cancer. [1] Here, we report a case of FLT3‑inter...
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ژورنال
عنوان ژورنال: Revista Brasileira de Hematologia e Hemoterapia
سال: 2017
ISSN: 1516-8484
DOI: 10.1016/j.bjhh.2017.03.001